---
title: Advancements in Gene Sequencing and the Role of Purified Water
description: Explore the evolution of gene sequencing and the crucial role of purified water in genomics research, featuring insights into modern technologies.
image: https://blog.veoliawatertechnologies.co.uk/hubfs/Advancements%20in%20Gene%20Sequencing%20and%20the%20Role%20of%20Purified%20Water.jpeg
---
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# Advancements in Gene Sequencing and the Role of Purified Water
by Peter Bridge
06 December 2018
3 minutes read
[ Back](https://blog.veoliawatertechnologies.co.uk) Follow
Next-generation gene sequencing has come a long way since the concept was explained in the 1970s. Here, we look at the technology's evolution and the importance of purified water in supporting genomics.
## The Evolution of Human Genome Understanding
What makes us human? This fundamental question has driven scientific inquiry for generations. While philosophers might approach this from a theoretical standpoint, the 1970s marked the beginning of a more literal understanding through genetic research. The groundbreaking discovery of DNA's structure by Watson and Crick in the 1950s initiated a five-decade journey, culminating in the complete sequencing of the human genome in 2003.
## Foundation of Modern Sequencing: The Sanger Method
The processes that revolutionised genetic research were first outlined in Sanger et al.'s seminal 1977 paper. The Sanger method ingeniously utilised the absence of a hydroxyl group on a 2',3'-dideoxynucleoside triphosphate (ddNTP) to attach a dideoxyribonucleotide to the chain's end. The addition of radioactive α\[32P\] enabled DNA visualisation through autoradiography, establishing the foundation for modern sequencing techniques.
## Next-Generation Sequencing: The Current Landscape
Next-generation sequencing (NGS) represents a quantum leap in DNA analysis capability. These technologies share the ability to parallel sequence millions of DNA templates simultaneously. The evolution from Sanger sequencing involves:
- Clonal amplification of DNA templates on solid support matrices
- Cyclic sequencing methodology
- Replacement of radioactive primers with fluorescent labels
- Advanced detection systems using sophisticated fluorimetry
## Modern Applications and Breakthroughs
The impact of NGS extends far beyond basic research:
Clinical Applications:
- Whole Genome Sequencing (WGS)
- Targeted disease research
- Personalised medicine protocols
Emerging Technologies:
- Long-read sequencing platforms
- AI-integrated genomic analysis
- Spatial transcriptomics
- Portable sequencing devices
## Critical Infrastructure: The Role of Ultra-Pure Water
While sequencing technology advances, the fundamental need for ultra-pure water remains constant. Modern laboratories require increasingly sophisticated water purification systems to maintain accuracy and reliability in genetic research.
### Point-of-Use Solutions
We offer advanced systems, including:
[Purelab® Chorus:](https://www.veoliawatertechnologies.co.uk/products/purelab-chorus-lab-water-systems)
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[Purelab® Quest:](https://www.veoliawatertechnologies.co.uk/products/purelabr-quest-pure-water-system)
- Compact footprint for space efficiency
- Three types of water quality output
- Ideal for labs with lower usage requirements
- User-friendly interface
[Purelab® Flex 3:](https://blog.veoliawatertechnologies.co.uk/introducing-the-purelab-flex-3-water-purification-system)
- Significantly reduced carbon footprint through sustainable materials
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- Superior water purification performance
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#### [CENTRA®:](https://www.veoliawatertechnologies.co.uk/products/centra)
- Complete purification, storage and distribution in single unit
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- Consistent water purity throughout distribution
- Economic operation for large-scale needs
## Selecting the Right Water Purification Solution
Choosing appropriate water purification equipment requires careful consideration of:
- Daily volume requirements
- Water quality specifications
- Laboratory layout and infrastructure
- Future scalability needs
For more tips on selecting the right water purification solution, [read our blog now.](https://blog.veoliawatertechnologies.co.uk/water-purification-for-scientific-labs-guide) For bespoke support, send a message to one of our experts [here](https://www.veoliawatertechnologies.co.uk/contact).
## Tags
- [Laboratory](https://blog.veoliawatertechnologies.co.uk/?tid=93395983598)
## Author | Peter Bridge
Peter has a background in analytical chemistry and has gained a wealth of knowledge and experience working for and supplying to a wide range of pharmaceutical, biotech customers and pharmaceutical companies.
[https://www.linkedin.com/in/peter-bridge-616a7423/](https://www.linkedin.com/in/peter-bridge-616a7423/)
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